¾ÅÉ«

Artavazd Badalyan is an Assistant Professor at the Department of Chemistry at the ¾ÅÉ«. He received his Ph.D. in Analytical Biochemistry from the University of Potsdam, Germany. He was a Postdoctoral ¾ÅÉ« Associate at the Department of Chemistry at the University of Wisconsin-Madison and a Project Leader at the internationally renowned company Dräger Safety AG in Germany. After this, he joined Utah State University as a Postdoctoral Fellow and changed his roles further to a ¾ÅÉ«er and a ¾ÅÉ« Assistant Professor.

The research in Badalyan lab focuses on the design, synthesis, and characterization of the biohybrid and bioinspired catalytic systems with novel properties that will have broad implications for selective environmental and biomedical sensors and chemical conversion and energy efforts. In addition, they study the properties of newly discovered CRISPR-Cas-nucleases and apply them for easy-to-use and ultrasensitive biosensors detecting viruses. Thus, their research allows students to gain and use their knowledge in biochemistry, biological and chemical catalysis, electrochemistry, and sensors development and learn modern electrochemical and spectroscopic techniques.

Ph.D. in Analytical Biochemistry, 2013
University of Potsdam

Diploma in Chemistry, 2008
Lomonosov Moscow State University

The research in Badalyan lab focuses on the design, synthesis, and characterization of the biohybrid and bioinspired catalytic systems with novel properties that will have broad implications for selective environmental and biomedical sensors and chemical conversion and energy efforts. In addition, we study the properties of newly discovered CRISPR-Cas-nucleases and apply them for easy-to-use and ultrasensitive biosensors detecting viruses. Thus, our research allows students to gain and use their knowledge in biochemistry, biological and chemical catalysis, electrochemistry, and sensor development and learn modern electrochemical and spectroscopic techniques.

• A non-covalently bound redox indicator for electrochemical CRISPR-Cas12a and DNase I biosensors
  ​Siler, T., Stanley, L., Saleem, M., Badalyan, A.*
  Anal. Chim. Acta 2025, 1336, 343480.
  DOI: 10.1016/j.aca.2024.343480
• A voltammetric study of nitrogenase MoFe-protein using low-potential electron transfer mediators
  ​Badalyan, A.,* Yang, Z.Y. & Seefeldt, L.C.*
  Bioelectrochemistry 2024, 155, 108575.
  DOI: 10.1016/j.bioelechem.2023.108575 | Supporting Info

Prior to the UL:

• The Fe protein cycle associated with nitrogenase catalysis requires the hydrolysis of two ATP for each single electron transfer event
  ​Yang, Z.Y., Badalyan, A., Hoffman, B.M., Dean, D.R. & Seefeldt, L.C.
  J. Am. Chem. Soc. 2023, 145, 5637-5644.
  DOI: 10.1021/jacs.2c09576 | Supporting Info
• Mechanistic insights into nitrogenase FeMo-cofactor catalysis through a steady-state kinetic model
  ​Harris, D.F.,* Badalyan, A.,* & Seefeldt, L.C.* 
  Biochemistry 2022, 61, 2131-2137.
  DOI: 10.1021/acs.biochem.2c00415 | Supporting Info
• A colorimetric method to measure in vitro nitrogenase functionality for engineering nitrogen fixation.
  ​Payá-Tormo, L., Coroian, D., Martín-Muñoz, S., Badalyan, A., Green, R., Veldhuizen, M., Jiang, X., López-Torrejón, G., Balk, J., Seefeldt, L., Burén, S., Rubio, L.M.
  Sci. Rep. 2022, 12, 10367.
  DOI: 10.1038/s41598-022-14453-x | Supporting Info
• Tailoring electron transfer pathway for photocatalytic N2-to-NH3 reduction in a CdS quantum dots-nitrogenase system
  Badalyan, A.,* Yang, Z.Y., Hu, M., Liu, T. Leo & Seefeldt, L.C.* 
  Sustain. Energy Fuels 2022, 6, 2256-2263.
  DOI: 10.1039/D2SE00148A | Supporting Info
• An efficient viologen-based electron donor to nitrogenase
  ​Badalyan, A.,* Yang, Z.Y., Hu, B., Luo, J., Hu, M., Liu, T. Leo & Seefeldt, L.C.* 
  Biochemistry 2019, 58, 4590-4595.
  DOI: 10.1021/acs.biochem.9b00844 | Supporting Info
• A voltammetric study of nitrogenase catalysis using electron transfer mediators
  ​Badalyan, A.,* Yang, Z.Y. & Seefeldt, L.C.* 
  ACS Catal. 2019, 9, 1366-1372.
  DOI: 10.1021/acscatal.8b04290 | Supporting Info
• Cooperative electrocatalytic alcohol oxidation with electron-proton-transfer mediators
  ​Badalyan, A. & Stahl, S.S.
  Nature 2016, 535, 406-410.
  DOI: 10.1038/nature18008 | Supporting Info
• Electrical wiring of the aldehyde oxidoreductase PaoABC with a polymer containing osmium redox centers: biosensors for benzaldehyde and GABA
  Badalyan, A., Dierich, M., Stiba, K., Schwuchow, V., Leimkühler, S. & Wollenberger, U.
  Biosensors 2014, 4, 403-421.
  DOI: 10.3390/bios4040403
• ​Dendritic polyglycerol–poly(ethylene glycol)-based polymer networks for biosensing application
  Dey, P., Adamovski, M., Friebe, S., Badalyan, A., Mutihac, R.-C., Paulus, F., Leimkühler, S., Wollenberger, U. & Haag, R.
  ACS Appl. Mater. Interfaces 2014, 6, 8937-8941.
  DOI: 10.1021/am502018x
• Analysis of the interaction of the molybdenum hydroxylase PaoABC from Escherichia coli with positively and negatively charged metal complexes
  ​Badalyan, A., Yoga, E. G., Schwuchow, V., Pöller, S., Schuhmann, W., Leimkühler, S. & Wollenberger, U. 
  Electrochem. Comm. 2013, 37, 5-7.
  DOI: 10.1016/j.elecom.2013.09.017
• A biosensor for aromatic aldehydes comprising the mediator dependent PaoABC-aldehyde oxidoreductase
  Badalyan, A., Neumann-Schaal, M., Leimkühler, S. & Wollenberger, U. 
  Electroanalysis 2013, 25, 101-108.
  DOI: 10.1002/elan.201200362
• Enzyme electrode for aromatic compounds exploiting the catalytic activities of microperoxidase-11
  Yarman, A., Badalyan, A., Gajovic-Eichelmann, N., Wollenberger, U. & Scheller, F. W.
  ​Biosens. Bioelectron. 2011, 30, 320-323.
  DOI: 10.1016/j.bios.2011.09.004